2. Alyssa Milano (Melrose Place/Charmed)
If Alyssa Milano first rose to fame in the ’80s thanks to her role in Madame is in Distress, the actress broke through in the ’90s with not one, but two cult series: Melrose Place (where she starred from 1997-1998) and Charmed (1998-2006).
After several unrealized series projects and appearing here and there (Earl, Breaking In), in 2013 she became one of the heroines of Mistresses, for two seasons. She also hosts the reality show Project Haute Couture: the finalists compete against each other. Activist Alyssa Milano was behind the #MeToo movement on social media in 2017. In recent years, fans of the actress could see her in Netflix’s Wet Hot American Summer: Ten Years Later and Insatiable. In 2019, she also reunited with her fellow Witches castmate Holly Marie Combs in an episode of Grey’s Anatomy.